Analysis of dopamine release and behavior in transgenic and 3-nitropropionic acid-treated Huntington’s Disease model rats
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چکیده
M. A. Johnson*, L. J. Steele, G. L. Osterhaus, J. C. Kraft, K. Lauderdale, S. C. Fowler , J. Pinkston, S. von Hörsten and O. Riess Department of Chemistry and R. N. Adams Institute for Bioanalytical Chemistry, Neuroscience Program, Department of Pharmacology and Toxicology, Schiefelbusch Institute for Life Span Studies, Lawrence, KS 66045 USA; Section for Experimental Therapy, Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, Germany; Department of Medical Genetics, University of Tubingen, Tubingen, Germany
منابع مشابه
Striatal dopamine levels and changes in mitochondrial function following chronic 3-nitropropionic acid treatment in rats
An irreversible inhibitor of complex II in the mitochondria, 3-nitropropionic acid (3-NP), induces bilateral striatal lesions with many neuropathological features of Huntington’s disease (HD) in rats. It is widely used as a model of HD. Chronic systemic treatment of 3-NP for 4 days in rats (10, 15 and 20 mg/kg) caused a significant dose-dependent reduction in succinate dehydrogenase activity, w...
متن کاملStriatal dopamine levels and changes in mitochondrial function following chronic 3-nitropropionic acid treatment in rats
An irreversible inhibitor of complex II in the mitochondria, 3-nitropropionic acid (3-NP), induces bilateral striatal lesions with many neuropathological features of Huntington’s disease (HD) in rats. It is widely used as a model of HD. Chronic systemic treatment of 3-NP for 4 days in rats (10, 15 and 20 mg/kg) caused a significant dose-dependent reduction in succinate dehydrogenase activity, w...
متن کاملDecreased striatal dopamine release underlies increased expression of long-term synaptic potentiation at corticostriatal synapses 24 h after 3-nitropropionic-acid-induced chemical hypoxia.
The striatum is particularly sensitive to the irreversible inhibitor of succinate dehydrogenase 3-nitropropionic acid (3-NP). In the present study, we examined early changes in behavior and dopamine and glutamate synaptic physiology created by a single systemic injection of 3-NP in Fischer 344 rats. Hindlimb dystonia was seen 2 h after 3-NP injections, and rats performed poorly on balance beam ...
متن کاملBeneficial effect of rice bran extract against 3-nitropropionic acid induced experimental Huntington's disease in rats
Huntington's disease (HD) is a neurodegenerative disorder, characterized by progressive motor and non-motor dysfunction due to degeneration of medium spiny neurons in striatum. 3-Nitropropionic acid is commonly used to induce the animal model of HD. Rice bran is supposed to have beneficial effects on mitochondrial function. The present study has been designed to explore the effect of rice bran ...
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Introdution: Parkinson's disease is the second most common neurodegenerative disease. Considering the antioxidant and neuroprotective properties of chlorogenic acid, the purpose of this study was to evaluate the neuroprotective effect of this substance in an experimental model of Parkinson's disease. Methods: In this experimental study, Wisar male rats (n = 32) were divided into 4 groups: sham...
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تاریخ انتشار 2008